Article
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Cell - 29 Oct 2020
Yurkovetskiy Leonid, Wang Xue, Pascal Kristen E, Tomkins-Tinch Christopher, Nyalile Thomas P, Wang Yetao, Baum Alina, Diehl William E, Dauphin Ann, Carbone Claudia, Veinotte Kristen, Egri Shawn B, Schaffner Stephen F, Lemieux Jacob E, Munro James B, Rafique Ashique, Barve Abhi, Sabeti Pardis C, Kyratsous Christos A, Dudkina Natalya V, Shen Kuang, Luban Jeremy
Abstract excerpt
The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near fixation in a matter of months. Here we show that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin. D614G...
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