Article

Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients

2020-06-03

Abstract excerpt

<h4>ABSTRACT</h4> The SARS-CoV-2 spike (S) protein, the viral mediator for binding and entry into the host cell, has sparked great interest as a target for vaccine development and treatments with neutralizing antibodies. Initial data suggest that the virus has low mutation rates, but its large genome could facilitate recombination, insertions, and deletions, as has been described in other coronaviruses. Here, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8b49a0d-b5e7-5d02-81ab-c3ad7a5dd243
DOI: 10.1101/2020.06.03.129585

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patientsDOI 10.1101/2020.06.03.129585Read

Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patientsSemantic proximity Read

The spike-stabilizing D614G mutation interacts with S1/S2 cleavage site mutations to promote the infectious potential of SARS-CoV-2 variantsSemantic proximity Read

S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitnessSemantic proximity Read

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants.Semantic proximity Read

The SARS-CoV-2 Spike Protein D614G Mutation Shows Increasing Dominance and May Confer a Structural Advantage to the Furin Cleavage DomainSemantic proximity Read

Genomic epidemiology reveals early transmission of SARS-CoV-2 and mutational dynamics in Nanning, ChinaSemantic proximity Read

Novel Polybasic Cleavage Site in SARS-CoV-2 Genome Is Likely to Induce a Major Change in the RNA Secondary StructureSemantic proximity Read

Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2Semantic proximity Read

Identification of a High-frequency Intra-host SARS-CoV-2 spike Variant with Enhanced Cytopathic and Fusogenic EffectSemantic proximity Read

The sequence of human ACE2 is suboptimal for binding the S spike protein of SARS coronavirus 2Semantic proximity Read

Systemic Effects of Missense Mutations on SARS-CoV-2 Spike Glycoprotein Stability and Receptor Binding AffinitySemantic proximity Read

SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic Variants.Semantic proximity Read