Article

Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects

2020-10-23

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2, a betacoronavirus, is the cause of the COVID-19 pandemic. The SARS-CoV-2 spike (S) glycoprotein trimer mediates virus entry into host cells and cytopathic effects. We studied the contribution of several S glycoprotein features to these functions, focusing on those that differ among related coronaviruses. Acquisition of the furin cleavage site by the SARS-CoV-2 S glycoprotein decrease...

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Identifiers and source

Literature Corpus work: 080bd8d5-09ca-5644-b8d1-d55575763a27
DOI: 10.1101/2020.10.22.351569

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