Article

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies

2024-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Whether neurodegenerative diseases linked to misfolding of the same protein share genetic risk drivers or whether different protein-aggregation pathologies in neurodegeneration are mechanistically related remains uncertain. Conventional genetic analyses are underpowered to address these questions. Through careful selection of patients based on protein aggregation phenotype (rather than clinical...

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Literature Corpus work: 77214aaa-6132-5b85-b921-d8e03ca3ba6a
DOI: 10.1101/2024.03.03.583145

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Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathiesDOI 10.1101/2024.03.03.583145Read

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