Article

Single cell transcriptomics reveals enrichment of aggregation-prone alpha-synuclein isoforms across synucleinopathies

2025-10-14

Abstract excerpt

Alpha-synuclein (a-Syn) is the primary component of Lewy bodies, the pathological hallmark of neurodegenerative synucleinopathies, including Parkinsons disease (PD) and dementia with Lewy bodies (DLB). Dysregulated expression of its encoding gene, SNCA, has been identified in association with both PD and DLB in short-read sequencing studies. However, such studies do not capture variation in transcript isoforms exp...

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Literature Corpus work: 3f476430-ddbe-54f2-b894-3f0301ab5f6d
DOI: 10.1101/2025.10.13.682119

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