Article
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
Science (New York, N.Y.) - 22 Nov 2013
Chung Chee Yeun, Khurana Vikram, Auluck Pavan K, Tardiff Daniel F, Mazzulli Joseph R, Soldner Frank, Baru Valeriya, Lou Yali, Freyzon Yelena, Cho Sukhee, Mungenast Alison E, Muffat Julien, Mitalipova Maisam, Pluth Michael D, Jui Nathan T, Schüle Birgitt, Lippard Stephen J, Tsai Li-Huei, Krainc Dimitri, Buchwald Stephen L, Jaenisch Rudolf, Lindquist Susan
Abstract excerpt
The induced pluripotent stem (iPS) cell field holds promise for in vitro disease modeling. However, identifying innate cellular pathologies, particularly for age-related neurodegenerative diseases, has been challenging. Here, we exploited mutation correction of iPS cells and conserved proteotoxic mechanisms from yeast to humans to discover and reverse phenotypic responses to α-synuclein (αsyn), a key protein...
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