Article

A Computational Atlas of Mutational Vulnerability Highlights Convergent Prion-Like and Aggregation-Associated Features in Neurodegenerative Proteins

2026-01-13

Abstract excerpt

<title>Abstract</title> <p>Cross-protein mutational susceptibility is not well understood, despite the fact that neurodegenerative diseases are caused by the misfolding, aggregation, and functional disruption of several proteins. Integrative analyses that combine mutational susceptibility patterns across several proteins implicated in neurodegenerative illness are lacking, despite the fact that prior research has...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab7db688-79bc-5f0b-876d-53a13618ae4c
DOI: 10.21203/rs.3.rs-8576121/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Computational Atlas of Mutational Vulnerability Highlights Convergent Prion-Like and Aggregation-Associated Features in Neurodegenerative ProteinsDOI 10.21203/rs.3.rs-8576121/v1Read

Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms.Semantic proximity Read

Molecular determinants of protein pathogenicity at the single-aggregate levelSemantic proximity Read

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleationSemantic proximity Read

Natural and Pathogenic Protein Sequence Variation Affecting Prion-Like Domains Within and Across Human ProteomesSemantic proximity Read

Leveraging AlphaFold 3 for Structural Modeling of Neurological Disorder-Associated Proteins: A Pathway to Precision MedicineSemantic proximity Read

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathiesSemantic proximity Read

The folding, dimerization and allosteric landscapes of the ALS protein SOD1: a comprehensive mutational atlasSemantic proximity Read

Understanding Genetic Risks: Computational Exploration of Human β-Synuclein nsSNPs and their Potential Impact on Structural Alteration.Semantic proximity Read

Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies.Semantic proximity Read

Molecular mechanisms of proteinopathies across neurodegenerative disease: a reviewSemantic proximity Read

Selective vulnerability to neurodegenerative disease: the curious case of Prion Protein.Semantic proximity Read