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Article

Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease.

BMC medical genomics - 21 Jan 2016

Dumitriu Alexandra, Golji Javad, Labadorf Adam T, Gao Benbo, Beach Thomas G, Myers Richard H, Longo Kenneth A, Latourelle Jeanne C

Abstract excerpt

BACKGROUND: Parkinson disease (PD) is a neurodegenerative disease characterized by the accumulation of alpha-synuclein (SNCA) and other proteins in aggregates termed "Lewy Bodies" within neurons. PD has both genetic and environmental risk factors, and while processes leading to aberrant protein aggregation are unknown, past work points to abnormal levels of SNCA and other proteins. Although several genome-wide...

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Identifiers

PMID: 26793951
DOI: 10.1186/s12920-016-0164-y
PMCID: PMC4722694

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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