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Article

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.

Nature genetics - 1 Mar 2009

Gitler Aaron D, Chesi Alessandra, Geddie Melissa L, Strathearn Katherine E, Hamamichi Shusei, Hill Kathryn J, Caldwell Kim A, Caldwell Guy A, Cooper Antony A, Rochet Jean-Christophe, Lindquist Susan

Abstract excerpt

Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, collectively referred to as synucleinopathies, are associated with a diverse group of genetic and environmental susceptibilities. The best studied of these is PD. alpha-Synuclein (alpha-syn) has a key role in the pathogenesis of both familial and sporadic PD, but evidence linking it to other predisposition factors is limited. Here we...

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Identifiers

PMID: 19182805
DOI: 10.1038/ng.300
PMCID: PMC2683786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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