Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

25 Jan 2017

Abstract excerpt

Numerous genes and molecular pathways are implicated in neurodegenerative proteinopathies, but their inter-relationships are poorly understood. We systematically mapped molecular pathways underlying the toxicity of alpha-synuclein (α-syn), a protein central to Parkinson's disease. Genome-wide screens in yeast identified 332 genes that impact α-syn toxicity. To "humanize" this molecular network, we developed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28131822
DOI: 10.1016/j.cels.2016.12.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular PathwaysPMID 28131822Read ↗

From yeast to patient neurons and back again: Powerful new discovery platformsSemantic proximity Read ↗

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathiesSemantic proximity Read ↗

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.Semantic proximity Read ↗

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s diseaseSemantic proximity Read ↗

Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease.Semantic proximity Read ↗

Understanding Genetic Risks: Computational Exploration of Human β-Synuclein nsSNPs and their Potential Impact on Structural Alteration.Semantic proximity Read ↗

Exploring Intrinsic Disorder in Human Synucleins and Associated Proteins.Semantic proximity Read ↗

A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation ApproachSemantic proximity Read ↗

Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.Semantic proximity Read ↗

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.Semantic proximity Read ↗

Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.Semantic proximity Read ↗

Yeast Reveal a “Druggable” Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in NeuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.