Article

Comparing Pathway-Informed Polygenic Risk Score Strategies: A multi-cohort evaluation of Amyloid-β

2026-05-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> To systematically evaluate pathway-informed polygenic risk score (PRS) strategies and determine which approaches most effectively leverage biological annotations for risk prediction, using brain amyloid-β (Aβ) positivity as a case study. <h4>Methods</h4> We systematically benchmarked approaches for integrating pathway information into PRSs construction to predict brain Aβ po...

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Literature Corpus work: 770657b6-53e3-5576-a587-db318ddbcfda
DOI: 10.64898/2026.05.25.26354071

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