Article

ML277 specifically enhances pore opening of KCNQ1 with VSD at the activated state by modulating VSD-pore coupling

2019-05-02

Abstract excerpt

In response to membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states that correspond to the stepwise activation of the voltage sensing domain (VSD) to the intermediate (I) and activated (A) states. In the heart, KCNQ1 associates with the auxiliary subunit KCNE1 to form the I Ks channel that regulates heart rhythm. More than 300 of loss-of-function KCNQ1 muta...

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Literature Corpus work: 7701776a-a78d-544e-b8e1-3220fc881170
DOI: 10.1101/624478

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