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Article

KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.

Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2010

Osteen Jeremiah D, Gonzalez Carlos, Sampson Kevin J, Iyer Vivek, Rebolledo Santiago, Larsson H Peter, Kass Robert S

Abstract excerpt

The delayed rectifier I(Ks) potassium channel, formed by coassembly of α- (KCNQ1) and β- (KCNE1) subunits, is essential for cardiac function. Although KCNE1 is necessary to reproduce the functional properties of the native I(Ks) channel, the mechanism(s) through which KCNE1 modulates KCNQ1 is unknown. Here we report measurements of voltage sensor movements in KCNQ1 and KCNQ1/KCNE1 channels using voltage clamp...

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Source

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Identifiers

PMID: 21149716
DOI: 10.1073/pnas.1016300108
PMCID: PMC3012494

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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