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Article

Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.

Nature communications - 29 Jun 2022

Willegems Katrien, Eldstrom Jodene, Kyriakis Efthimios, Ataei Fariba, Sahakyan Harutyun, Dou Ying, Russo Sophia, Van Petegem Filip, Fedida David

Abstract excerpt

The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K+ recycling in organs including the heart, brain, and gut. Loss of function is relatively common and can cause sudden arrhythmic death, sudden infant death, epilepsy and deafness. Here, we report cryogenic electron microscopic (cryo-EM) structures of Xenopus KCNQ1 bound to Ca2+/Calmodulin, with and without the KCNQ1 channel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35768468
DOI: 10.1038/s41467-022-31526-7
PMCID: PMC9243137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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