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Article

Insights into Cardiac IKs (KCNQ1/KCNE1) Channels Regulation

11 Dec 2020

Abstract excerpt

The delayed rectifier potassium IKs channel is an important regulator of the duration of the ventricular action potential. Hundreds of mutations in the genes (KCNQ1 and KCNE1) encoding the IKs channel cause long QT syndrome (LQTS). LQTS is a heart disorder that can lead to severe cardiac arrhythmias and sudden cardiac death. A better understanding of the IKs channel (here called the KCNQ1/KCNE1 channel)...

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PMID: 33322401
DOI: 10.3390/ijms21249440

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Related research

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