Article
KCNQ1 K+ channel-mediated cardiac channelopathies.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2006
Loussouarn Gildas, Baró Isabelle, Escande Denis
Abstract excerpt
KCNQ1 is a voltage-activated potassium channel alpha-subunit expressed in various cell types, including cardiac myocytes and epithelial cells. KCNQ1 associates with different beta-subunits of the KCNE protein family. In the human heart, KCNQ1 associates with KCNE1 to generate the IKs current characterized by its slow activation and deactivation kinetics. Mutations in either KCNQ1 or KCNE1 are responsible for at...
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