Article

Molecular simulations reveal a mechanism for enhanced allosteric coupling between voltage-sensor and pore domains in KCNQ1 explaining its activation by ML277

2022-05-31

Abstract excerpt

The voltage-gated potassium channel KCNQ1 (K V 7.1) is important for the repolarizing phase of the cardiac action potential. Activators of KCNQ1 may provide a strategy for the pharmacological treatment of congenital long QT syndrome, a genetic disorder caused by pathogenic variants in KCNQ1 that promote arrhythmia susceptibility and elevate risk for sudden cardiac death. The small-molecule agonist ML277 recovers...

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Literature Corpus work: 0dfe2f18-3c21-59bd-bc72-4ffe4ea2b246
DOI: 10.1101/2022.05.31.494217

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