Article

Spatial Transcriptomic Evidence Consistent with Reactivation of Embryonic Neural Pathways in Amyotrophic Lateral Sclerosis

2026-08-05

Abstract excerpt

<title>Abstract</title> <p>Background: Neurodegenerative diseases may involve the aberrant reactivation of developmental programs that are normally silenced after embryogenesis. We hypothesized that amyotrophic lateral sclerosis (ALS) is associated with reactivation of an embryonic cytoskeletal program centered on the Arp2/3 actin nucleation complex, actomyosin contractility, intracellular transport, and developm...

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Literature Corpus work: 7cfe0822-df70-5877-a0d6-a984b39f87d8
DOI: 10.21203/rs.3.rs-10579730/v1

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