Article

Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma

2022-10-11

Abstract excerpt

<title>Abstract</title> <p>Neuroblastoma (NB) is one of the most lethal childhood cancers due its propensity to treatment resistance. By spatial mapping of subclone geographies before and after chemotherapy across 89 tumor regions from 12 NBs, we find that densely packed territories of closely related subclones present at diagnosis are replaced under effective treatment by islands of distantly related survivor su...

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Literature Corpus work: 76c9745d-fffc-5940-bea8-5100c620c2a4
DOI: 10.21203/rs.3.rs-2104205/v1

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