Article
Clonal evolution during metastatic spread in high-risk neuroblastoma.
Nature genetics - 1 Jun 2023
Gundem Gunes, Levine Max F, Roberts Stephen S, Cheung Irene Y, Medina-Martínez Juan S, Feng Yi, Arango-Ossa Juan E, Chadoutaud Loic, Rita Mathieu, Asimomitis Georgios, Zhou Joe, You Daoqi, Bouvier Nancy, Spitzer Barbara, Solit David B, Dela Cruz Filemon, LaQuaglia Michael P, Kushner Brian H, Modak Shakeel, Shukla Neerav, Iacobuzio-Donahue Christine A, Kung Andrew L, Cheung Nai-Kong V, Papaemmanuil Elli
Abstract excerpt
Patients with high-risk neuroblastoma generally present with widely metastatic disease and often relapse despite intensive therapy. As most studies to date focused on diagnosis-relapse pairs, our understanding of the genetic and clonal dynamics of metastatic spread and disease progression remain limited. Here, using genomic profiling of 470 sequential and spatially separated samples from 283 patients, we...
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