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Article

Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling

19 Feb 2015

Abstract excerpt

INTRODUCTION: High-risk neuroblastoma (HR-NB) presenting with hematogenous metastasis is one of the most difficult cancers to cure. Patient survival is poor. Aggressive tumors contain populations of rapidly proliferating clonogens that exhibit stem cell properties, cancer stem cells (CSCs). Conceptually, CSCs that evade intensive multimodal therapy dictate tumor progression, relapse/recurrence, and poor clinical...

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PMID: 25888913
DOI: 10.1186/s13287-015-0002-8

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