Article
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Nature communications - 23 Nov 2021
Schmelz Karin, Toedling Joern, Huska Matt, Cwikla Maja C, Kruetzfeldt Louisa-Marie, Proba Jutta, Ambros Peter F, Ambros Inge M, Boral Sengül, Lodrini Marco, Chen Celine Y, Burkert Martin, Guergen Dennis, Szymansky Annabell, Astrahantseff Kathy, Kuenkele Annette, Haase Kerstin, Fischer Matthias, Deubzer Hedwig E, Hertwig Falk, Hundsdoerfer Patrick, Henssen Anton G, Schwarz Roland F, Schulte Johannes H, Eggert Angelika
Abstract excerpt
Intratumour heterogeneity is a major cause of treatment failure in cancer. We present in-depth analyses combining transcriptomic and genomic profiling with ultra-deep targeted sequencing of multiregional biopsies in 10 patients with neuroblastoma, a devastating childhood tumour. We observe high spatial and temporal heterogeneity in somatic mutations and somatic copy-number alterations which are reflected on the...
Topics
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
- Biopsy
- Child
- Child, Preschool
- Clinical Decision-Making
- Clinical Trials, Phase III as Topic