Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.

Nature - 20 Jan 2011

Notta Faiyaz, Mullighan Charles G, Wang Jean C Y, Poeppl Armando, Doulatov Sergei, Phillips Letha A, Ma Jing, Minden Mark D, Downing James R, Dick John E

Abstract excerpt

Many tumours are composed of genetically diverse cells; however, little is known about how diversity evolves or the impact that diversity has on functional properties. Here, using xenografting and DNA copy number alteration (CNA) profiling of human BCR-ABL1 lymphoblastic leukaemia, we demonstrate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p15
Share to Fusion Proteins, bcr-abl
Share to Genes, p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Neoplasm Transplantation

Share to Philadelphia Chromosome

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 21248843
DOI: 10.1038/nature09733

Genes

ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21248843-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.PMID 21248843Read ↗

Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment.Semantic proximity Read ↗

Genetic variegation of clonal architecture and propagating cells in leukaemia.Semantic proximity Read ↗

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell GenomicsSemantic proximity Read ↗

Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.Semantic proximity Read ↗

Clonal evolution of acute leukemia genomes.Semantic proximity Read ↗

Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.Semantic proximity Read ↗

Clonal competition within complex evolutionary hierarchies shapes AML over time.Semantic proximity Read ↗

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.Semantic proximity Read ↗

Clonal evolution and tumor-initiating cells: New dimensions in cancer patient treatment.Semantic proximity Read ↗

Clonal Evolution of High-Risk Chronic Lymphocytic Leukemia: A Contemporary PerspectiveSemantic proximity Read ↗

Clonal evolution of acute myeloid leukemia highlighted by latest genome sequencing studies.Semantic proximity Read ↗

Extensive Clonal Branching Shapes the Evolutionary History of High-Risk Pediatric CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.