Article
Mutational topography reflects clinical neuroblastoma heterogeneity
2022-03-07
Abstract excerpt
<title>Abstract</title> <p>Neuroblastoma is a pediatric solid tumor characterized by strong clinical heterogeneity. Although certain complex genomic alterations, such as extrachromosomal DNA amplifications (ecDNA), have been recurrently detected in neuroblastomas, the mutational processes involved in their generation remain largely unclear. By examining the topography of complex rearrangements along with mutation...
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Identifiers and source
- Literature Corpus work
- 956b7742-ac7f-585f-87b6-ba3b64f3e443
- DOI
- 10.21203/rs.3.rs-1396291/v1