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Article

Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma.

Nature communications - 18 Oct 2024

Karlsson Jenny, Yasui Hiroaki, Mañas Adriana, Andersson Natalie, Hansson Karin, Aaltonen Kristina, Jansson Caroline, Durand Geoffroy, Ravi Naveen, Ferro Michele, Yang Minjun, Chattopadhyay Subhayan, Paulsson Kajsa, Spierings Diana, Foijer Floris, Valind Anders, Bexell Daniel, Gisselsson David

Abstract excerpt

Neuroblastoma (NB) is one of the most lethal childhood cancers due to its propensity to become treatment resistant. By spatial mapping of subclone geographies before and after chemotherapy across 89 tumor regions from 12 NBs, we find that densely packed territories of closely related subclones present at diagnosis are replaced under effective treatment by islands of distantly related survivor subclones,...

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Share to Antineoplastic Agents
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Evolution

Share to Clone Cells

Share to Drug Resistance, Neoplasm

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Share to Xenograft Model Antitumor Assays

Source

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Identifiers

PMID: 39419962
DOI: 10.1038/s41467-024-53334-x
PMCID: PMC11486966

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