Article

Clonal evolution during metastatic spread in high-risk neuroblastoma

2022-08-15

Abstract excerpt

High-risk neuroblastoma is generally metastatic and often lethal. Using genomic profiling of 470 sequential and spatially separated samples from 283 patients, we characterize subtype-specific genetic evolutionary trajectories from diagnosis, through progression and end-stage metastatic disease. Clonal tracing timed disease initiation to embryogenesis. Continuous acquisition of structural variants at disease defini...

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Literature Corpus work: 07d2f706-f4c2-553e-91a7-7074ebaf7697
DOI: 10.1101/2022.08.15.503973

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