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Article

CHAMP1 is an essential regulator for human myoblast fusion and muscle development.

Nature communications - 15 Jan 2026

Zhang Haifeng, Zhou Min, Zhang Zheng, Wang Zhaoning, Shi Ruifeng, Wang Yushu, Wei Xiaolin, Shang Renjie, Li Jianwen, He Cuiyu, Xie Jin, Diao Yarui, Bi Pengpeng

Abstract excerpt

Human skeletal muscle comprises myofibers formed by fusion of thousands of myoblasts. This process depends on tightly regulated, muscle-specific fusogens, but its genetic control remains poorly understood. Here, we identify CHAMP1 (Chromosome Alignment Maintaining Phosphoprotein 1) as essential for human myoblast fusion in vitro and in vivo. Genomic and protein-interaction assays reveal a noncanonical role for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41540007
DOI: 10.1038/s41467-025-67584-w
PMCID: PMC12808755

Genes

CHAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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