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Article

Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation.

Genes & development - 1 Jun 2013

Sebastian Soji, Faralli Hervé, Yao Zizhen, Rakopoulos Patricia, Palii Carmen, Cao Yi, Singh Kulwant, Liu Qi-Cai, Chu Alphonse, Aziz Arif, Brand Marjorie, Tapscott Stephen J, Dilworth F Jeffrey

Abstract excerpt

Alternate splicing contributes extensively to cellular complexity by generating protein isoforms with divergent functions. However, the role of alternate isoforms in development remains poorly understood. Mef2 transcription factors are essential transducers of cell signaling that modulate differentiation of many cell types. Among Mef2 family members, Mef2D is unique, as it undergoes tissue-specific splicing to...

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Source

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Identifiers

PMID: 23723416
DOI: 10.1101/gad.215400.113
PMCID: PMC3690398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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