Article

Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit

2025-09-02

Abstract excerpt

<h4>ABSTRACT</h4> Mechanical loading drives structural and functional improvements in muscle and tendon, protecting against injury at their interface – the myotendinous junction (MTJ) – and within the tendon matrix. However, the early cellular and molecular events that initiate these adaptations in humans remain poorly understood. To investigate this, we applied single nucleus RNA sequencing and in situ hybridiza...

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Literature Corpus work: 7afdf791-9025-533c-a108-949f27a1792c
DOI: 10.1101/2025.08.28.672815

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Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unitDOI 10.1101/2025.08.28.672815Read

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