Article

Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

2024-03-04

Abstract excerpt

Genomic loci associated with common traits and diseases are typically non-coding and likely impact gene expression, sometimes coinciding with rare loss-of-function variants in the target gene. However, our understanding of how gradual changes in gene dosage affect molecular, cellular, and organismal traits is currently limited. To address this gap, we induced gradual changes in gene expression of four genes using...

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Literature Corpus work: 2348bf27-e723-5ca3-9b87-e6cf9b26360b
DOI: 10.1101/2024.03.01.582837

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