Article

Gene expression profiling reveals B cells are highly educated by the pancreatic environment during autoimmune diabetes

2022-05-20

Abstract excerpt

B cells play an important role in driving the development of type 1 diabetes, however, it remains unclear how they contribute to local beta-cell destruction during disease progression. Using gene expression profiling of B cell subsets in the pancreas and pancreatic lymph nodes, we reveal that B cells are highly modified by the inflamed pancreatic tissue and can be distinguished by their transcriptional profile fro...

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Literature Corpus work: 766ef9f7-950c-5c37-a0ed-7258202a28f0
DOI: 10.1101/2022.05.19.492647

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