Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer.

doi:10.1158/0008-5472.CAN-20-3773

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Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer.

Cancer research - 15 Aug 2021

Harris Robert J, Cheung Anthony, Ng Joseph C F, Laddach Roman, Chenoweth Alicia M, Crescioli Silvia, Fittall Matthew, Dominguez-Rodriguez Diana, Roberts James, Levi Dina, Liu Fangfang, Alberts Elena, Quist Jelmar, Santaolalla Aida, Pinder Sarah E, Gillett Cheryl, Hammar Niklas, Irshad Sheeba, Van Hemelrijck Mieke, Dunn-Walters Deborah K, Fraternali Franca, Spicer James F, Lacy Katie E, Tsoka Sophia, Grigoriadis Anita, Tutt Andrew N J, Karagiannis Sophia N

Abstract excerpt

In breast cancer, humoral immune responses may contribute to clinical outcomes, especially in more immunogenic subtypes. Here, we investigated B lymphocyte subsets, immunoglobulin expression, and clonal features in breast tumors, focusing on aggressive triple-negative breast cancers (TNBC). In samples from patients with TNBC and healthy volunteers, circulating and tumor-infiltrating B lymphocytes (TIL-B) were...

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PMID: 34224371
DOI: 10.1158/0008-5472.CAN-20-3773
PMCID: PMC7611538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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