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Article

Transcriptome-Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass-Specific Phenotypes.

European journal of immunology - 1 Mar 2026

Koers Jana, Hoogendijk Arie J, Tol Simon, Van Alphen Floris P J, Derksen Ninotska I L, van den Biggelaar Maartje, Rispens Theo

Abstract excerpt

Antibodies produced by B cells aid in the recognition and clearance of pathogens and are the cornerstone of vaccination strategies. Humans produce nine different antibody isotypes, and their effector functions differ according to the type of antigen and route of exposure. Phenotypic variation between isotype-switched B cell subsets is expected but not studied in detail. To obtain a molecular definition of...

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Identifiers

PMID: 41817307
DOI: 10.1002/eji.70159
PMCID: PMC12981214

Genes

CD27
SDR16C5

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