Article

BCL6 in T cells promotes type 1 diabetes by redirecting fates of insulin-autoreactive B lymphocytes

2025-08-28

Abstract excerpt

Currently approved type 1 diabetes (T1D) immunotherapies broadly target T cells and delay but do not fully prevent diabetes development, highlighting the need for more selective targets. Anti-insulin germinal center B cells are uniquely able to present pathogenic insulin epitopes and drive anti-insulin T cells to adopt a T follicular helper fate. T cell expression of BCL6, a key transcriptional repressor in the ge...

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Literature Corpus work: cbc762a7-b4fa-5065-8d0f-d3c032e6c0ac
DOI: 10.1101/2025.08.25.671997

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