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Article

Global reference mapping of human transcription factor footprints.

Nature - 1 Jul 2020

Vierstra Jeff, Lazar John, Sandstrom Richard, Halow Jessica, Lee Kristen, Bates Daniel, Diegel Morgan, Dunn Douglas, Neri Fidencio, Haugen Eric, Rynes Eric, Reynolds Alex, Nelson Jemma, Johnson Audra, Frerker Mark, Buckley Michael, Kaul Rajinder, Meuleman Wouter, Stamatoyannopoulos John A

Abstract excerpt

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits1, but it remains challenging to distinguish variants that affect regulatory function2. Genomic DNase I footprinting enables the quantitative, nucleotide-resolution delineation of sites of transcription...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Regulatory Sequences, Nucleic Acid

Source

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Identifiers

PMID: 32728250
DOI: 10.1038/s41586-020-2528-x
PMCID: PMC7410829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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