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Enhancer variants associated with Alzheimer’s disease affect gene expression via chromatin looping

9 Sept 2019

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms (SNPs) that may be genetic factors underlying Alzheimer's disease (AD). However, how these AD-associated SNPs (AD SNPs) contribute to the pathogenesis of this disease is poorly understood because most of them are located in non-coding regions, such as introns and intergenic regions. Previous studies reported that...

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PMID: 31500627
DOI: 10.1186/s12920-019-0574-8

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