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A human neuronal model of sporadic Alzheimer’s disease induced by <i>FBXO2</i> downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment

2024-09-03

Abstract excerpt

Sporadic Alzheimer’s disease (sAD) arises from a complex interplay between genetic and environmental factors that remains poorly understood, making it challenging to develop accurate cell models. To address this problem, by hypothesing that the early disease sAD states can be characterised by transcriptomic fingerprints, we assessed the effect on Aβ aggregation in human neuroblastoma cells a set of genes obtained...

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Literature Corpus work
53c98a4b-16fa-50f4-9b21-e9b08a50e8ec
DOI
10.1101/2024.09.01.610673
Open publication

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A human neuronal model of sporadic Alzheimer’s disease induced by <i>FBXO2</i> downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairmentDOI 10.1101/2024.09.01.610673
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