Article

Identification of enhancer chromatin signatures involved in dopaminergic induction through multi-omics analysis

2025-08-15

Abstract excerpt

The establishment of precise transcriptional programs during neuronal development depends on a complex and dynamic landscape of regulatory elements. Here, we combined histone modification ChIP-seq, chromatin accessibility profiling, and transcriptomics to map active enhancer repertoires during the differentiation of human embryonic stem cells into midbrain dopaminergic neurons. Our integrative analysis revealed th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f2c0428-24d6-5a1b-991a-18c5f3023492
DOI: 10.1101/2025.08.14.670306

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of enhancer chromatin signatures involved in dopaminergic induction through multi-omics analysisDOI 10.1101/2025.08.14.670306Read

Dynamic landscape of chromatin accessibility and transcriptomic changes during differentiation of human embryonic stem cells into dopaminergic neurons.Semantic proximity Read

Multi-layered regulatory networks driving human dopaminergic neuron differentiationSemantic proximity Read

Extending cis-regulatory networks using chromatin-RNA interactionsSemantic proximity Read

Specialised super-enhancer networks in stem cells and neuronsSemantic proximity Read

Transcriptional Enhancers: Bridging the Genome and Phenome.Semantic proximity Read

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cellsSemantic proximity Read

Enhancer biology and enhanceropathies.Semantic proximity Read

Bridging between mouse and human enhancer-promoter long-range interactions in neural stem cells, to understand enhancer function in neurodevelopmental diseaseSemantic proximity Read

Long-Range Enhancer Networks Gradually Emerge as Key Regulators During Human Cortical NeurogenesisSemantic proximity Read

Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoidsSemantic proximity Read

Validation of Enhancer Regions in Primary Human Neural Progenitor Cells using Capture STARR-seqSemantic proximity Read

ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28ASemantic proximity Read