In silico peptide self-assembly reveals the importance of N-terminal motifs and the inhibition mechanism of the mutation L38M in α-synuclein fibrillation.

Abstract excerpt

Alpha-synuclein (αSyn) is a presynaptic protein associated with several neurodegenerative diseases. While the non-amyloid component (NAC) region of the αSyn sequence (residues 65-90) forms the core of all αSyn fibrils, recent findings suggest that the flanking regions play a key role in initiating or preventing amyloid formation. Two motifs in the N-terminal region, named P1 (αSyn [36-42]) and P2 (αSyn [45-57]),...

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