Article

Transcription factor binding sites are frequently under accelerated evolution in primates

2022-04-30

Abstract excerpt

Recent comparative genomic studies have identified many human accelerated elements (HARs) with elevated substitution rates in the human lineage. However, it remains unknown to what extent transcription factor binding sites (TFBSs) are under accelerated evolution in humans and other primates. Here, we introduce two pooling-based phylogenetic methods with dramatically enhanced sensitivity to examine accelerated evol...

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Literature Corpus work: 0de27b30-9c23-5700-93e3-6a9d83819dc9
DOI: 10.1101/2022.04.29.490094

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