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Article

Lineage-specific regulatory evolution: insights from massively parallel reporter assays.

Current opinion in genetics & development - 1 Aug 2025

Easterlin Ryder, Ahituv Nadav

Abstract excerpt

Lineage-specific genetic variants play a key role in evolutionary divergence, particularly through changes in cis-regulatory elements that fine-tune gene expression. Massively parallel reporter assays (MPRAs) provide a powerful approach to characterize these variants at scale. This review highlights how MPRAs have been used to study lineage-specific regulatory activity in enhancer elements, including human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40543151
DOI: 10.1016/j.gde.2025.102372
PMCID: PMC13215266

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