Article

Co-evolution between colibactin production and resistance is linked to clonal expansions in <i>Escherichia coli</i>

2025-11-17

Abstract excerpt

Specific strains of Escherichia coli employ the polyketide synthase island to produce a metabolite called colibactin that is implicated in colorectal tumorigenesis via its genotoxic effect on human DNA. However, the damage to host DNA is essentially collateral from ecological competition during bacterial colonisation, where colibactin is used to displace other gut bacteria. Despite intensive recent research on co...

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Literature Corpus work: 75675f6a-8a75-5dcb-9999-d118c03cbe6f
DOI: 10.1101/2025.11.17.686825

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