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Article

Colibactin leads to a bacteria-specific mutation pattern and self-inflicted DNA damage.

Genome research - 20 Sept 2024

Lowry Emily, Wang Yiqing, Dagan Tal, Mitchell Amir

Abstract excerpt

Colibactin produced primarily by Escherichia coli strains of the B2 phylogroup cross-links DNA and can promote colon cancer in human hosts. Here, we investigate the toxin's impact on colibactin producers and on bacteria cocultured with producing cells. Using genome-wide genetic screens and mutation accumulation experiments, we uncover the cellular pathways that mitigate colibactin damage and reveal the specific...

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Identifiers

PMID: 39152036
DOI: 10.1101/gr.279517.124
PMCID: PMC11444178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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