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Article

Pre-existing chromosomal polymorphisms in pathogenic <i>E. coli</i> potentiate the evolution of antibiotic resistance by MCR-1 plasmid acquisition

2022-02-20

Abstract excerpt

Bacterial pathogens show high levels of standing genetic diversity, but the influence of this diversity on the evolution of antibiotic resistance remains unclear. Here we address this problem in the context of colistin, a ‘last line of defense’ antibiotic. Using experimental evolution, we show that a plasmid carrying the MCR-1 colistin resistance gene dramatically increases the ability of E. coli populations to e...

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Identifiers and source

Literature Corpus work
82843482-00b6-52e8-8054-141310f74dc6
DOI
10.1101/2022.02.20.481192
Open publication

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Pre-existing chromosomal polymorphisms in pathogenic <i>E. coli</i> potentiate the evolution of antibiotic resistance by MCR-1 plasmid acquisitionDOI 10.1101/2022.02.20.481192
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