Back to search

Article

Genomic characterization of <i>Escherichia coli</i> harbor a polyketide synthase ( <i>pks</i> ) island associated with colorectal cancer (CRC) development

2024-06-17

Abstract excerpt

The E. coli strain harboring the polyketide synthase ( Pks) island encodes the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer. The present study involved whole-genome-wide comparison and phylogenetic analysis of pks harboring E. coli isolates to gain insight into the distribution and evolution of these organism. Fi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c345c95e-9acd-56c0-b7bd-d1760be7c359
DOI
10.1101/2024.06.16.599199
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genomic characterization of <i>Escherichia coli</i> harbor a polyketide synthase ( <i>pks</i> ) island associated with colorectal cancer (CRC) developmentDOI 10.1101/2024.06.16.599199
Evolutionary Dynamics Based on Comparative Genomics of Pathogenic Escherichia coli Lineages Harboring Polyketide Synthase (pks) Island.Semantic proximity
Insights into the acquisition of the <i>pks</i> island and production of colibactin in the <i>Escherichia coli</i> populationSemantic proximity
Contribution of pks+ Escherichia coli (E. coli) to Colon CarcinogenesisSemantic proximity
Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population.Semantic proximity
Genetic diversity, phylogroup distribution and virulence gene profile of pks positive Escherichia coli colonizing human intestinal polyps.Semantic proximity
Colibactin possessing E. coli isolates in association with colorectal cancer and their genetic diversity among Pakistani population.Semantic proximity
Comparative genomics of DH5α-inhibiting <i>Escherichia coli</i> isolates from human feces reveals common co-occurrence of bacteriocin genes with virulence factors and antibiotic resistance genesSemantic proximity
Co-evolution between colibactin production and resistance is linked to clonal expansions in <i>Escherichia coli</i>Semantic proximity
The bacterial genetic determinants of <i>Escherichia coli</i> capacity to cause bloodstream infections in humansSemantic proximity
Pks+ Escherichia Coli More Prevalent in Benign than Malignant Colorectal TumorsSemantic proximity
Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survivalSemantic proximity
Characterization of Polyketide Synthase Machinery from the <i>pks</i> Island Facilitates Isolation of a Candidate PrecolibactinSemantic proximity
Select a neighboring publication to make it the new centre.