Article

Diversity and prevalence of colibactin- and yersiniabactin encoding mobile genetic elements in enterobacterial populations: insights into evolution and co-existence of two bacterial secondary metabolite determinants

2021-01-23

Abstract excerpt

<h4>1 Abstract</h4> The bacterial genotoxin colibactin interferes with the eukaryotic cell cycle by causing double-stranded DNA breaks. It has been linked to bacterially induced colorectal cancer in humans. Colibactin is encoded by a 54-kb genomic region in Enterobacteriaceae . The colibactin genes commonly co-occur with the yersiniabactin biosynthetic determinant. Investigating the prevalence and sequence diver...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 519a4b16-abe6-5f6f-8860-876776e9c721
DOI: 10.1101/2021.01.22.427840

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diversity and prevalence of colibactin- and yersiniabactin encoding mobile genetic elements in enterobacterial populations: insights into evolution and co-existence of two bacterial secondary metabolite determinantsDOI 10.1101/2021.01.22.427840Read

Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.Semantic proximity Read

Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli populationSemantic proximity Read

Co-evolution between colibactin production and resistance is linked to clonal expansions in Escherichia coliSemantic proximity Read

Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population.Semantic proximity Read

Colibactin DNA damage signature indicates causative role in colorectal cancerSemantic proximity Read

The microbiome-product colibactin hits unique cellular targets mediating host–microbe interactionSemantic proximity Read

Programmable conjugative CRISPR interference targeting genotoxin in the gutSemantic proximity Read

Pangenome analysis of Enterobacteria reveals richness of secondary metabolite gene clusters and their associated gene setsSemantic proximity Read

Genomic characterization of Escherichia coli harbor a polyketide synthase ( pks ) island associated with colorectal cancer (CRC) developmentSemantic proximity Read

Assessment of Genotoxic Escherichia coli and Helicobacter pylori Pathogenicity in the Context of Gastrointestinal Carcinogenesis in a Turkish CohortSemantic proximity Read

Analysis of the partial sequencing of clbA, clbB and clbQ in Escherichia coli isolates that produce colibactin and multilocus sequence typing.Semantic proximity Read

Colibactin leads to a bacteria-specific mutation pattern and self-inflicted DNA damage.Semantic proximity Read