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Article

TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease.

International journal of molecular sciences - 17 Feb 2023

Chen Yi-Chun, Chang Shih-Cheng, Lee Yun-Shien, Ho Wei-Min, Huang Yu-Hua, Wu Yah-Yuan, Chu Yi-Chuan, Wu Kuan-Hsuan, Wei Li-Shan, Wang Hung-Li, Chiu Ching-Chi

Abstract excerpt

Translocase of outer mitochondrial membrane 40 (TOMM40) is located in the outer membrane of mitochondria. TOMM40 is essential for protein import into mitochondria. TOMM40 genetic variants are believed to increase the risk of Alzheimer's disease (AD) in different populations. In this study, three exonic variants (rs772262361, rs157581, and rs11556505) and three intronic variants (rs157582, rs184017, and )...

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Identifiers

PMID: 36835494
DOI: 10.3390/ijms24044085
PMCID: PMC9962462

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