Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ALDH2 activation protects against mutant TOMM40-mediated mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.

Life sciences - 15 Apr 2026

Chen Yi-Chun, Chiu Tai-Ju, Wu Yah-Yuan, Wang Yu-Ting, Wu Kuan-Hsuan, Yeh Tu-Hsueh, Hsieh Ya-Ju, Chen Wan-Shia, Chiu Ching-Chi

Abstract excerpt

AIMS: TOMM40 (translocase of outer mitochondrial membrane 40) is crucial for mitochondrial protein import. Mutations in TOMM40 increase the risk of Alzheimer's disease (AD) and trigger neuroinflammation. ALDH2 (aldehyde dehydrogenase 2) has neuroprotective effects, but the therapeutic role of ALDH2 activation in targeting neuroinflammation-induced AD remains unclear. MATERIALS AND METHODS: In this study, it was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase, Mitochondrial
Share to Benzamides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Benzodioxoles

Share to Hippocampus

Share to Microglia

Share to Mitochondrial Precursor Protein Import Complex Proteins

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Reactive Oxygen Species

Source

Identifiers

PMID: 41692154
DOI: 10.1016/j.lfs.2026.124274

Genes

TOMM40
ALDH2
NLRP3
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALDH2 activation protects against mutant TOMM40-mediated mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.PMID 41692154Read ↗

TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease.Semantic proximity Read ↗

Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer’s diseaseSemantic proximity Read ↗

<i>TOMM40</i> suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer’s diseaseSemantic proximity Read ↗

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease.Semantic proximity Read ↗

Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in MicrogliaSemantic proximity Read ↗

Mitochondria Dysfunction and Neuroinflammation in Neurodegeneration: Who Comes First?Semantic proximity Read ↗

Mitochondrial DNA and Inflammation in Alzheimer’s DiseaseSemantic proximity Read ↗

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.Semantic proximity Read ↗

Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegenerationSemantic proximity Read ↗

TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ <sub>42</sub> in HMC3 cellsSemantic proximity Read ↗

Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer’s DiseaseSemantic proximity Read ↗

Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.