Article

TOMM40-APOE chimera linking Alzheimer’s highest risk genes: a new pathway for mitochondria regulation and APOE4 pathogenesis

2024-10-10

Abstract excerpt

<h4>Summary</h4> The patho-mechanism of apolipoprotein variant, APOE4, the strongest genetic risk for late-onset Alzheimer’s disease (AD) and longevity, remains unclear. APOE’s neighboring gene, TOMM40 (mitochondria protein transport channel), is associated with brain trauma outcome and aging-related cognitive decline, however its role in AD APOE4-independently is controversial. We report that TOMM40 is prone to...

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Literature Corpus work: 4d390528-bbf1-5c77-8ea7-71452a501f90
DOI: 10.1101/2024.10.09.617477

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