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Article

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells

12 Oct 2009

Abstract excerpt

Replicated sister chromatids are held together until mitosis by cohesin, a conserved multisubunit complex comprised of Smc1, Smc3, Scc1, and Scc3, which in vertebrate cells exists as two closely related homologues (SA1 and SA2). Here, we show that cohesin(SA1) and cohesin(SA2) are differentially required for telomere and centromere cohesion, respectively. Cells deficient in SA1 are unable to establish or maintain...

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Share to Chromosomal and Genetic Variations
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Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 19822671
DOI: 10.1083/jcb.200903096

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